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Orih and Ntuen  

Full Length Research Paper

The Usefulness of Urinary Fibronectin as an Early Marker of Glomerular Injury in Type 2 Diabetes Mellitus Patients



Department of Chemical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State Nigeria.


Corresponding author email:mikeorih@yahoo.com; Tel: +2348035455171

Received February 27, 2017; Accepted March 16, 2017


About one-third of diabetes is complicated by diabetic kidney disease. It is even challenging in type 2 diabetics in which this complication may occur before the presentation. Traditionally, microalbuminuria is the first marker of early diabetic kidney disease. However, it has many limitations, including developing when significant kidney damage has already occurred. This study aimed at determining the urinary fibronectin excretion levels in type 2 diabetic without complications and in the control group. This was a hospital-based cross-sectional study, consisting of 120 type 2 diabetics without complications and 120 apparently healthy non-diabetic/hypertensive as controls. Microalbuminuria was measured using Immunoturbidimetric assay while urinary fibronectin was measured using ELISA technique. Statistical analysis was done using statistical package for social science version 20. A p-value of less than 0.05 was considered statistically significant. Urinary fibronectin was significantly higher in type 2 diabetics in comparison to the control group (1.29 ± 1.69 µg/ml vs 0.29 ± 0.31 µg/ml, p < 0.001). Based on Albumin-Creatinine-Ratio, 27.5% of the type 2 diabetics were micro albuminuric as compared to none in the controls. There was a significant positive correlation between urinary fibronectin and microalbuminuria (r- 0.23; p= 0.013). The sensitivity of urinary fibronectin was 93.9%, negative predictive value was 77.8% and area under the curve of 0.0830 in the receiver operating characteristics (ROC) curve. Urinary fibronectin is a useful early biomarker in the renal evaluation of type 2 diabetics.

Diabetic Kidney Disease, Microalbuminuria, Urinary Fibronectin.


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