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Umelo et al  

Full Length Research Paper

Seroprevalence and Risk Factors for Cytomegalovirus and Herpes Simplex Virus Infections among Pregnant Women in Irrua, Nigeria

 

Umelo CC1, Eifediyi RA1,2*, Jombo SE1, Oriaifo N1, Eigbefoh JO1,2

1Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
2Department of Obstetrics and Gynaecology, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.

 

Corresponding author email: agbonsreuben@yahoo.com

Received November 14, 2017; Accepted November 30, 2017

 

ABSTRACT
Cytomegalovirus (CMV) is the most common congenital infection and viral based mental retardation and hearing deficit in children of developing countries. Herpes simplex virus (HSV) infections are associated with congenital and neonatal herpetic infections. Developing countries have high prevalence and treatment of maternal infection has no beneficial effect on fetal outcome. This study aim to evaluate the seroprevalence, the risk factors for CMV and HSV infections among pregnant women attending the antenatal clinic in ISTH, Irrua. A descriptive cross sectional study conducted among antenatal attendee of Irrua Specialist Teaching Hospital, Irrua. Structured questionnaire was used to gather socio-demographic data. Two TORCHES rapid test kits was used to detect CMV / HSV specific immunoglobulin M antibody (IgM). Seroprevalence of CMV IgM in the study was 1.0%, HSV-1 5.0% and HSV-2 2.7%. Seroprevalence of CMV was observed to increase with maternal age. Being unmarried and of low parity were positively related to the seroprevalence of HSV-1 and 2 (P<0.001). Coinfection with HCV and HIV infection was statistically related to CMV infection (P <0.001). Although seroprevalence of CMV and HSV-1 and 2 was low it was associated with significant adverse pregnancy outcomes. The risk factors identified can aid screening, early diagnosis and treatment.


Keywords: 
Cytomegalovirus, Herpes Simplex, Antenatal screening, Seroprevalence and Risk factors.

 

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