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Meseret et al  

 

Full Length Research Paper


Pathological Changes in the Nervous System of Horse Naturally Affected By Dourine in Arsi-Bale Highlands, Ethiopia

 

1Melke Meseret, 2Hagos Ashenafi and 3*Solomon Tsegayeh

 

1Alage Agricultural Technical Vocational Educational Training College, Department of Animal Health, P.O.Box: 2589, Ziway, Ethiopia.
2Addis Ababa University, College of Veterinary Medicine and Agriculture, Department of Veterinary Parasitology and Pathology, P.O.Box: 34; Debre Zeit, Ethiopia.
3Woldia University, College of Agriculture; P.O.Box= 400, Woldia, Ethiopia.

 

Corresponding author email: solomontsegaye25@gmail.com

Received November 29, 2016; Accepted January 12, 2017
ABSTRACT

 

A cross-sectional study was done in three selected districts of horse-breeding in the Arsi–Bale highlands of Ethiopia. The present study was aimed at investigating the effect of natural infection by Trypanosoma equipper dum (dourine) in horses, determining the pathological lesions the nervous system, and to reveal the presence of the parasite in the nervous tissue or cerebrospinal fluid or in both. For this purpose, we used two horses having clinically positive and strong seropositive result in Card Agglutination Test for Trypanosomosis (CATT) test and a post-mortem examination and followed by a histopathological test. Pathological lesions in the nervous system of infected animals included degenerative changes and neuronal necrosis, which were more pronounced in the lumbar and sacral parts of spinal cord than cervical and thoracic parts and brain tissues, and cellular infiltration and degeneration in the left sciatic nerve than the right sciatic nerve. The pathological lesions were associated with the absence of the parasite (in Giemsa stain) and viral infection (in cell culture) related to increased immunological reactions.

 

Keywords: Arsi–Bale highlands, Dourine, Ethiopia, Histopathology, Horses.

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